Albendazole and mebendazole uptake by isolated enterocytes.

Abstract

Uptake of albendazole (ABZ) and mebendazole (MBZ) by isolated rat enterocytes was carried out. These drugs, widely used oral anthelmintics, exhibit a scarce water solubility which reduce its absorption by the oral tract. The present study was designed to assess the captation for ABZ and MBZ in different enterocyte populations isolated from upper to crypt villus. The concentration range used for the absorption experiments was within 10-500 microM for both drugs, using DMSO as solvent. The results obtained show the existence of a passive mechanism for the uptake of ABZ and MBZ at concentrations between 10 and 100 microM, with a maximum intake value around 20 microM/mg protein. No differences were found with respect to the cell populations analyzed. The drug uptake levels seem to be higher for MBZ than for ABZ prior to reaching the maximum plateau.

Cite this paper

@article{Villaverde1992AlbendazoleAM, title={Albendazole and mebendazole uptake by isolated enterocytes.}, author={Carmen Villaverde and Ana Isabel Alvarez and J L del Estal and Julio Gabriel Prieto}, journal={Developmental pharmacology and therapeutics}, year={1992}, volume={19 1}, pages={27-31} }