Albaconol from the mushroom Albatrellus confluens induces contraction and desensitization in guinea pig trachea.

@article{Yang2003AlbaconolFT,
  title={Albaconol from the mushroom Albatrellus confluens induces contraction and desensitization in guinea pig trachea.},
  author={Weimin Yang and Jikai Liu and Chen Qing and Yi-Dan Liu and Z Q Ding and Zhiqiang Shen and Zhi-He Chen},
  journal={Planta medica},
  year={2003},
  volume={69 8},
  pages={715-9}
}
The contraction and desensitization induced by albaconol and the influence of capsazepine, capsaicin and extracellular Ca2+ were investigated to see whether the actions were mediated via a specific VR receptor in guinea pig trachea spiral strips in vitro. Both albaconol and capsaicin were contractors of tracheal smooth muscle, but albaconol was not so potent as capsaicin, with -log (M) EC50 values of 4.23 +/- 0.18 (n = 10) and 7.33 +/- 0.21 (n = 10) respectively. 2.5 microM capsazepine… CONTINUE READING