Alanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport in oxidatively stressed Caco-2 cells.

@article{Alteheld2005AlanylglutamineDA,
  title={Alanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport in oxidatively stressed Caco-2 cells.},
  author={Birgit Alteheld and Mary E. Evans and Li Hao Gu and Vadivel Ganapathy and Frederick H. Leibach and D. H. P. Jones and Thomas R. Ziegler},
  journal={The Journal of nutrition},
  year={2005},
  volume={135 1},
  pages={19-26}
}
Reactive oxygen species (ROS) produced by gut mucosal cells during conditions such as inflammatory bowel disease (IBD) may impair mucosal repair and nutrient transport/absorptive function. Absorption of di- and tripeptides in the small intestine and colon is mediated by the H(+)-dependent transporter PepT1, but effects of oxidative stress on di- and tripeptide transport are unknown. We assessed whether exposure to hydrogen peroxide (H(2)O(2)) influences dipeptide transport in human colonic… CONTINUE READING

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