Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction.

@article{Khan2012AlantolactoneIA,
  title={Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction.},
  author={Muhammad Xaaceph Khan and Fei Yi and Azhar Rasul and Ting Li and Nan Wang and Hongwen Gao and Rong Gao and Tonghui Ma},
  journal={IUBMB life},
  year={2012},
  volume={64 9},
  pages={783-94}
}
Glioblastoma multiforme (GBM) is the most malignant and aggressive primary brain tumor in adults. Despite concerted efforts to improve current therapies, the prognosis of glioblastoma remains very poor. Alantolactone, a sesquiterpene lactone compound, has been reported to exhibit antifungal, antibacteria, antihelminthic, and anticancer properties. In this study, we found that alantolactone effectively inhibits growth and triggers apoptosis in glioblastoma cells in a time- and dose-dependent… CONTINUE READING
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