Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity

  title={Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity},
  author={Feng Qiu and Jun-jie Wang and Gerhard Dahl},
  journal={Purinergic Signalling},
Pannexin1 is a prime candidate to represent an ATP release channel. The pannexin1 channel can be activated by extracellular ATP through purinergic receptors P2X7 or P2Y. Recent studies have shown that the Pannexin1 channel is inhibited by its own permeant ion, ATP, and also by P2X7 receptor agonists and antagonists. However, the dose dependence of this inhibition indicated that significant inhibition was prominent at ATP concentrations higher than required for activation of purinergic receptors… CONTINUE READING

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