Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.

@article{Yang2009AlanineAI,
  title={Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.},
  author={Rong-Ze Yang and Soohyun Park and Armando R. Irizarry Rovira and Rick Goldstein and Shao Bo Zhong and Michael T. Lawton and Francis Rajamohan and Kun Qian and Li Liu and Da-Wei Gong},
  journal={Hepatology},
  year={2009},
  volume={49 2},
  pages={
          598-607
        }
}
UNLABELLED The elevation of serum alanine aminotransferase (ALT) is regarded as an indicator of liver damage based on the presumption that ALT protein is specifically and abundantly expressed in the liver. However, ALT elevation is also observed in non-liver injury conditions (for example, muscle injury) and in apparently healthy people. Conversely, serum ALT activity is normal in many patients with confirmed liver diseases (for example, cirrhosis and hepatitis C infection). To improve the… CONTINUE READING
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