Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats.

@article{Dhar2010AlagebriumAA,
  title={Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats.},
  author={Arti Dhar and Kaushik M. Desai and Ling-Yun Wu},
  journal={British journal of pharmacology},
  year={2010},
  volume={159 1},
  pages={166-75}
}
BACKGROUND AND PURPOSE Alagebrium is a breaker of cross-links in advanced glycation endproducts. However, the acute effects of alagebrium on methylglyoxal (MG), a major precursor of advanced glycation endproducts have not been reported. MG is a highly reactive endogenous metabolite, and its levels are elevated in diabetic patients. We investigated whether alagebrium attenuated the acute effects of exogenous MG on plasma MG levels, glucose tolerance and distribution of administered MG in… CONTINUE READING

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