Aladapcin, a new microbial metabolite that enhances host resistance against bacterial infection. Production, isolation, physico-chemical properties and biological activities.

@article{Shiraishi1990AladapcinAN,
  title={Aladapcin, a new microbial metabolite that enhances host resistance against bacterial infection. Production, isolation, physico-chemical properties and biological activities.},
  author={Akio Shiraishi and Mutsuo Nakajima and T Katayama and Takuya Matsuda and Tomizo Niwa and Takao Okazaki and Yasuyuki Takamatsu and Hidemi. Nagaki and Taisei Kinoshita and Toshio Takatsu},
  journal={The Journal of antibiotics},
  year={1990},
  volume={43 6},
  pages={
          634-8
        }
}
We have constructed a new screening system for detecting microbial products that enhance host resistance against bacterial infection. It was found that a new compound with such activity is produced by a soil isolate classified as Nocardia sp. SANK 60484. The compound was isolated from the culture filtrate of the organism and named aladapcin after its amino acid composition. Aladapcin was obtained as an amphoteric white amorphous powder with the molecular formula, C13H25N5O5. It consists of 2… 
3 Citations

Figures and Tables from this paper

Detection of novel secondary metabolites.

This review focuses on the genesis and development of the gamut of methodologies that have led to the successful detection of the wide variety of novel secondary metabolites that include antibacterial, antigungal, antiviral and antitumour antibiotics, enzyme inhibitors, pharmacologically and immunologically active agents, products useful in agriculture and animal husbandry, microbial regulators, and other compounds for which no bioactive role has yet been found.

References

SHOWING 1-7 OF 7 REFERENCES

Effects of a New Antibiotic, Isohematinic Acid, on the Resistance of Mice to Experimental Infections

Results suggest that isohematinic acid, like BM 12,531, enhances nonspecific resistance to these bacterial infections by stimulating the microbicidal activity of PMN and inducing leucocytosis.

Studies on a new immunoactive peptide, FK-156. II. Fermentation, extraction and chemical and biological characterization.

Pretreatment of mice or rats with this peptide protected the animals against lethal infection with Escherichia coli and resulted in prolongation of life span of tumor bearing animals.

Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs.

N-Acetylmuramyl-L-alanyl-D-isoglutamine and four other synthetic adjuvants that are structural analogs of part of the mycobacterial peptidoglycan monomer are shown to enhance the nonspecific immunity

Enhanced superoxide anion release from phagocytes by muramyl dipeptide or lipopolysaccharide

MDP enhanced NADPH oxidase activity of macrophages, which is probably the reason for enhanced O2- release by MDP.

Enhancement ofnonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogues

  • Proc. Natl. Acad. Sci. U.S.A
  • 1977

Structure and mass fragmentation patterns of aladapcin