Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild‐type paralytic poliomyelitis

  title={Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild‐type paralytic poliomyelitis},
  author={Elin Kindberg and Cecilia Ax and Lucia Fiore and Lennart Svensson},
  journal={Journal of Medical Virology},
Poliovirus infections can be asymptomatic or cause severe paralysis. Why some individuals develop paralytic poliomyelitis is unknown, but a role for host genetic factors has been suggested. To investigate if a polymorphism, Ala67Thr, in the poliovirus receptor, which has been found to facilitate increased resistance against poliovirus‐induced cell lysis and apoptosis, is associated with increased risk of paralytic poliomyelitis, poliovirus receptor genotyping was undertaken among Italian… 
Ala67Thr Mutation in the Human Polio Virus Receptor (PVR) Gene inPost-Polio Syndrome Patients
Clinical and demographic characteristics of the PPS individuals who were affected initially by poliomyelitis and later developed PPS are presented and changes in the PVR gene may result in slowly progressive cytopathic effects that may lead to progression of PPS.
Assay for identification of heterozygous single-nucleotide polymorphism (Ala67Thr) in human poliovirus receptor gene
The SNP detection assay was successfully developed for identification of Ala67Thr polymorphism in human PVR/CD155 gene and will be useful for large scale screening of DNA samples.
Genetic Determinants of Enterovirus Infections: Polymorphisms in Type 1 Diabetes and Innate Immune Genes in the MIDIA Study.
No evidence for strong associations with enterovirus presence in stool samples from Norwegian children is found, but among a number of SNPs in candidate genes, clear evidence for rejection of the complete null hypothesis is found.
Associations between Single Nucleotide Polymorphisms in Cellular Viral Receptors and Attachment Factor-Related Genes and Humoral Immunity to Rubella Vaccination
It is indicated that multiple SNPs from genes involved in cell adhesion, viral attachment, and viral entry play a role in modulating humoral immune responses following live rubella vaccination.
Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient
The use of whole exome sequencing to uncover possible contributions of host genetics to the development of disease outcome in humans with poliomyelitis suggests that ATG7 defect contributes to host susceptibility to PV infection and proposes autophagy as an unapp appreciated antiviral effector in viral infection in humans.
Protection against poliomyelitis in Europe.
The reappearance of circulating wild poliovirus type 1 (WPV 1) in Tajikistan is the first outbreak from imported wild poliovirus since the World Health Organization (WHO) European Region was declared
Rapid communications Protection against poliomyelitis in Europe
The reappearance of circulating wild poliovirus type 1 (WPV 1) in Tajikistan is the first outbreak from imported wild poliovirus since the World Health Organization (WHO) European Region was declared
The Role of Integrins in Enterovirus Infections and in Metastasis of Cancer
The role of integrins in the pathogenesis of metastasis to cortical bone and on type 1 diabetes (T1D) and echovirus 1 infection is studied and a possible correlation between susceptibility to enteringovirus infections in diabetic children and differences in enterovirus receptor genes was investigated.
Back signaling of HLA class I molecules and T/NK cell receptor ligands in epithelial cells reflects the rejection‐specific microenvironment in renal allograft biopsies
  • J. Egelkamp, E. Chichelnitskiy, C. Falk
  • Biology, Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2019
Evidence that epithelial cells may contribute to the rejection process and pave the way to a better understanding of the pathomechanisms of kidney allograft rejection is provided.


Variation in enterovirus receptor genes
Both synonymous and nonsynonymous sequence variability of genes coding for enterovirus and rhinovirus receptors was shown to occur, but no pattern directly specific for type 1 diabetes was found.
Nucleotide variation in Sabin type 2 poliovirus from an immunodeficient patient with poliomyelitis.
This is the first case of poliomyelitis and long-term excretion from an immunodeficient patient to be reported in Italy through the active 'Acute Flaccid Paralysis' surveillance system.
Persistence of vaccine-derived polioviruses among immunodeficient persons with vaccine-associated paralytic poliomyelitis.
This group of patients with vaccine-associated paralytic poliomyelitis appears to be an unlikely source of poliovirus reintroduction in developed countries because of the rarity and high fatality rate of iVAPP and the possible spontaneous clearance ofPolioviruses.
The role of the Polio Virus Receptor and the Herpesvirus entry mediator B genes for the development of MS
Epidemiology of poliomyelitis in the United States one decade after the last reported case of indigenous wild virus-associated disease.
  • P. Strebel, R. Sutter, A. Hinman
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1992
It is suggested that adoption of a sequential vaccination schedule (inactivated poliovirus vaccine followed by OPV) would be effective in decreasing the risk of VAPP while retaining the proven public health benefits of OPV.
Vaccine-associated paralytic poliomyelitis: a retrospective cohort study of acute flaccid paralyses in Brazil.
Cases of AFP who received OPV between 4 and 40 days before the onset of paralysis and had fever, a prodrome of gastrointestinal symptoms, history of first dose of OPV, isolation of vaccine poliovirus type 2, and young age deserve careful investigation, since they are at increased risk for the condition studied.
Expression of mutated poliovirus receptors in human neuroblastoma cells persistently infected with poliovirus.
Functional analysis of PVR in murine LM cells showed that the PVR forms selected during persistent infection conferred on LM cells partial resistance to PV1/Mahoney-induced lysis, indicating that these mutations increased the resistance of cells to PV- induced lysis.
Amino acid residues on human poliovirus receptor involved in interaction with poliovirus.
A polymorphism in the poliovirus receptor gene differs in motor neuron disease
Differences in the poliovirus receptor gene may result in slowly progressive viral cytopathic effects that lead to lower motor neuron forms of motor neuron disease.