Akt3 is a privileged first responder in isozyme-specific electrophile response.

@article{Long2017Akt3IA,
  title={Akt3 is a privileged first responder in isozyme-specific electrophile response.},
  author={Marcus J. C. Long and Saba Parvez and Yi Zhao and Sanjna L Surya and Yiran Wang and Sheng Zhang and Yimon Aye},
  journal={Nature chemical biology},
  year={2017},
  volume={13 3},
  pages={
          333-338
        }
}
Isozyme-specific post-translational regulation fine tunes signaling events. However, redundancy in sequence or activity renders links between isozyme-specific modifications and downstream functions uncertain. Methods to study this phenomenon are underdeveloped. Here we use a redox-targeting screen to reveal that Akt3 is a first-responding isozyme sensing native electrophilic lipids. Electrophile modification of Akt3 modulated downstream pathway responses in cells and Danio rerio (zebrafish) and… CONTINUE READING
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