Akt2 regulates cardiac metabolism and cardiomyocyte survival.

  title={Akt2 regulates cardiac metabolism and cardiomyocyte survival.},
  author={Brian J DeBosch and Nandakumar Sambandam and Carla J. Weinheimer and Michael Courtois and Anthony J. Muslin},
  journal={The Journal of biological chemistry},
  volume={281 43},
The Akt family of serine-threonine kinases participates in diverse cellular processes, including the promotion of cell survival, glucose metabolism, and cellular protein synthesis. All three known Akt family members, Akt1, Akt2 and Akt3, are expressed in the myocardium, although Akt1 and Akt2 are most abundant. Previous studies demonstrated that Akt1 and Akt3 overexpression results in enhanced myocardial size and function. Yet, little is known about the role of Akt2 in modulating cardiac… CONTINUE READING
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