Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.

@article{Etzion2010Akt2DP,
  title={Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.},
  author={Sharon Etzion and Yoram Etzion and Brian J DeBosch and Peter A. Crawford and Anthony J. Muslin},
  journal={Journal of molecular and cellular cardiology},
  year={2010},
  volume={49 6},
  pages={931-40}
}
Patients with diabetes mellitus can develop cardiac dysfunction in the absence of underlying coronary artery disease or hypertension; a condition defined as diabetic cardiomyopathy. Mice lacking the intracellular protein kinase Akt2 develop a syndrome that is similar to diabetes mellitus type 2. Expression profiling of akt2(-/-) myocardium revealed that Rab4a, a GTPase involved in glucose transporter 4 translocation and β-adrenergic receptor (βAR) recycling to the plasma membrane, was… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…