Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells.

@article{Yun2014Akt1IM,
  title={Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells.},
  author={Sung Ji Yun and Jung Min Ha and Eun Kyoung Kim and Young Whan Kim and Seo Yeon Jin and Dong Hyung Lee and Sang Heon Song and Chi Dae Kim and Hwa Kyoung Shin and Sun Sik Bae},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1842 11},
  pages={
          2184-92
        }
}
In this study, we investigated the role of Akt1 isoform in phenotypic change of vascular smooth muscle cells (VSMCs) and neointima formation. Laminin-induced conversion of synthetic VSMCs into contractile VSMCs was measured by expression of marker proteins for contractile VSMCs and collagen gel contraction assay. Culture of synthetic VSMCs on laminin-coated plates induced expression of marker proteins for contractile VSMCs and showed contraction in response to angiotensin II (AngII) stimulation… CONTINUE READING

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