Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

Abstract

The activation of the Akt signalling in response to cytokine receptor signalling promotes protein synthesis, cellular growth and proliferation. To determine the role of Akt in interleukin-3 (IL-3) signalling, we generated IL-3-dependent myeloid cell lines from mice lacking Akt1, Akt2 or Akt3. Akt1 deletion resulted in accelerated apoptosis at low… (More)
DOI: 10.1038/cdd.2013.63

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