Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function.

@article{Balu2012Akt1DI,
  title={Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function.},
  author={Darrick T Balu and Gregory C. Carlson and Konrad Talbot and Hala Altaf Kazi and Tiffany E. Hill-Smith and Rachel M Easton and Morris J Birnbaum and Irwin Lucki},
  journal={Hippocampus},
  year={2012},
  volume={22 2},
  pages={230-40}
}
Genetic studies have associated deficient function of the serine/threonine kinase Akt1 with schizophrenia. This disorder is associated with developmental, structural, and functional abnormalities of the hippocampus that could be traced to abnormal Akt1 function. To establish a closer connection between Akt1 and hippocampal function, mice with a selective deletion of Akt1 (Akt1(-/-) mice) were examined for physiological and behavioral outcomes dependent on the hippocampus and associated with… CONTINUE READING