Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning.

@article{Lai2006Akt1DA,
  title={Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning.},
  author={W. M. Lai and Bin Xu and Koen G C Westphal and Marta Paterlini and Berend Olivier and Paul Pavlidis and Maria Karayiorgou and Joseph A Gogos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 45},
  pages={
          16906-11
        }
}
There is accumulating evidence that AKT signaling plays a role in the pathogenesis of schizophrenia. We asked whether Akt1 deficiency in mice results in structural and functional abnormalities in prefrontal cortex (PFC). Exploratory transcriptional profiling revealed concerted alterations in the expression of PFC genes controlling synaptic function, neuronal development, myelination, and actin polymerization, and follow-up ultrastructural analysis identified consistent changes in the dendritic… CONTINUE READING
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