Akt1 and Akt2 promote peripheral B-cell maturation and survival.

  title={Akt1 and Akt2 promote peripheral B-cell maturation and survival.},
  author={Marco Calamito and Marisa M. Juntilla and Matthew J. Thomas and Daniel L Northrup and Jeffrey C. Rathmell and Morris J Birnbaum and Gary A Koretzky and David Allman},
  volume={115 20},
Although the 3 isoforms of Akt regulate cell growth, proliferation, and survival in a wide variety of cell types, their role in B-cell development is unknown. We assessed B-cell maturation in the bone marrow (BM) and periphery in chimeras established with fetal liver progenitors lacking Akt1 and/or Akt2. We found that the generation of marginal zone (MZ) and B1 B cells, 2 key sources of antibacterial antibodies, was highly dependent on the combined expression of Akt1 and Akt2. In contrast, Akt1… CONTINUE READING


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Development of immunoglobulin lambda-chainpositive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals

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