Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

@article{Juntilla2007Akt1AA,
  title={Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.},
  author={Marisa M. Juntilla and Jessica A. Wofford and Morris J Birnbaum and Jeffrey C. Rathmell and Gary A Koretzky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 29},
  pages={12105-10}
}
The beta-selection checkpoint in alphabetaT lymphocyte development occurs at the double negative (DN) 3 (CD4(-)CD8(-)CD25(+)c-kit(-)) stage, when further differentiation requires a signal from the newly rearranged TCR beta chain. Thymocytes with mutations in key signaling molecules in the phosphatidylinositol 3-kinase-Akt pathway manifest defects in survival, proliferation, and differentiation past the beta-selection checkpoint. However, little information is available regarding the role of Akt… CONTINUE READING

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