Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes.

@article{Zhou2015Akt1proteinKB,
  title={Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes.},
  author={Huanyu Zhou and Matthew Edmund Dickson and Min Soo Kim and Rhonda Bassel-Duby and Eric N Olson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 38},
  pages={
          11864-9
        }
}
Conversion of fibroblasts to functional cardiomyocytes represents a potential approach for restoring cardiac function after myocardial injury, but the technique thus far has been slow and inefficient. To improve the efficiency of reprogramming fibroblasts to cardiac-like myocytes (iCMs) by cardiac transcription factors [Gata4, Hand2, Mef2c, and Tbx5 (GHMT)], we screened 192 protein kinases and discovered that Akt/protein kinase B dramatically accelerates and amplifies this process in three… CONTINUE READING

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