Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

@article{Lin2001AktSA,
  title={Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.},
  author={H K Lin and Shuyuan Yeh and Hye Yoon Kang and Chawnshang Chang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 13},
  pages={7200-5}
}
Whereas several apoptosis-related proteins have been linked to the antiapoptotic effects of Akt serine-threonine kinase, the search continues to explain the Akt signaling role in promoting cell survival via antiapoptotic effects. Here, we demonstrate that Akt phosphorylates the androgen receptor (AR) at Ser-210 and Ser-790. A mutation at AR Ser-210 results in the reversal of Akt-mediated suppression of AR transactivation. Activation of the phosphatidylinositol-3-OH kinase/Akt pathway results in… CONTINUE READING
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