Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.


Mammalian target of rapamycin (mTOR), a well known Akt substrate, regulates multiple cellular functions including cell growth and protein synthesis. The current study identifies a novel role of the Akt/mTOR pathway as a regulator of CNS myelination. Previously, we showed that overexpressing constitutively active Akt in oligodendrocytes in a transgenic mouse… (More)
DOI: 10.1523/JNEUROSCI.0232-09.2009


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