Akt regulates nuclear/cytoplasmic localization of tuberin

@article{Rosner2007AktRN,
  title={Akt regulates nuclear/cytoplasmic localization of tuberin},
  author={Margit Rosner and Angelika Freilinger and Markus Hengstschlaeger},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={521-531}
}
The autosomal dominantly inherited disease tuberous sclerosis (TSC) affects ∼1 in 6000 individuals and is characterized by the development of tumors, named hamartomas, in different organs. TSC1, encoding hamartin, and TSC2, encoding tuberin are tumor suppressor genes responsible for TSC. Hamartin and tuberin form a complex, of which tuberin is assumed to be the functional component. The TSC proteins have been implicated in the control of cell cycle by activating the cyclin-dependent kinase… CONTINUE READING
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References

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Showing 1-5 of 5 references

J Biol Chem 281: 8313–8316

  • JL Rosa
  • Dan HC, Sun M, Yang L, Feldman RI, Sui X-M, Ou CC…
  • 2006

Cell 121: 179–193

  • Pandolfi PP.
  • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley…
  • 2005
1 Excerpt

Oncogene 24: 7475–7481

  • A Astrinidis, Henske EP.
  • Astrinidis A, Senapedis W, Henske EP. (2006). Hum…
  • 2005

Nat Med 8: 1153–1160

  • K Han
  • Lejbkowicz F, Goyer C, Darveau A, Neron S…
  • 2002

J Biol Chem 273: 20535–20539

  • DJ, Noonan DJ.
  • Inoki K, Li Y, Zhu T, Wu J, Guan K-L. (2002). Nat…
  • 1998

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