Akt regulates nuclear/cytoplasmic localization of tuberin

  title={Akt regulates nuclear/cytoplasmic localization of tuberin},
  author={Margit Rosner and Angelika Freilinger and Markus Hengstschlaeger},
The autosomal dominantly inherited disease tuberous sclerosis (TSC) affects ∼1 in 6000 individuals and is characterized by the development of tumors, named hamartomas, in different organs. TSC1, encoding hamartin, and TSC2, encoding tuberin are tumor suppressor genes responsible for TSC. Hamartin and tuberin form a complex, of which tuberin is assumed to be the functional component. The TSC proteins have been implicated in the control of cell cycle by activating the cyclin-dependent kinase… CONTINUE READING
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