Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation.

@article{Vojtek2003AktRB,
  title={Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation.},
  author={Anne B. Vojtek and Jennifer Taylor and Stacy L. DeRuiter and Jenn-Yah Yu and Claudia Figueroa and Roland P. S. Kwok and David L. Turner},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 13},
  pages={
          4417-27
        }
}
Neural basic helix-loop-helix (bHLH) transcription factors regulate neurogenesis in vertebrates. Signaling by peptide growth factors also plays critical roles in regulating neuronal differentiation and survival. Many peptide growth factors activate phosphatidylinositol 3-kinase (PI3K) and subsequently the Akt kinases, raising the possibility that Akt may impact bHLH protein function during neurogenesis. Here we demonstrate that reducing expression of endogenous Akt1 and Akt2 by RNA interference… CONTINUE READING

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