Akt plays an important role in breast cancer cell chemotaxis to CXCL12

@article{Zhao2007AktPA,
  title={Akt plays an important role in breast cancer cell chemotaxis to CXCL12},
  author={Mingming Zhao and Barbara M. Mueller and Richard G. Discipio and Ingrid U. Schraufstatter},
  journal={Breast Cancer Research and Treatment},
  year={2007},
  volume={110},
  pages={211-222}
}
The chemokine receptor CXCR4 is functionally expressed on the cell surface of various cancer cells, and plays a role in cell proliferation and migration of these cells. Specifically, in breast cancer cells the CXCR4/CXCL12 axis has been implicated in cell migration in vitro and in metastasis in vivo, but the underlying signaling mechanisms are incompletely understood. The xenograft-derived MDA-MB-231 breast cancer cell line (231mfp), which was shown previously to grow more aggressively than the… CONTINUE READING

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