Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism.

  title={Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism.},
  author={Marcin Kortylewski and Florian Feld and K A Krueger and Gregor Bahrenberg and Richard A. Roth and Hans-Georg Joost and Peter Claus Heinrich and Iris Behrmann and Andreas Barthel},
  journal={The Journal of biological chemistry},
  volume={278 7},
The phosphatidylinositol 3-kinase/Akt pathway plays an important role in the signaling of insulin and other growth factors, which reportedly attenuate the interleukin-6 (IL-6)-mediated stimulation of acute phase plasma protein genes. We investigated the effect of the protein kinase Akt on IL-6-mediated transcriptional activation. The transient expression of constitutively active Akt inhibited the IL-6-dependent activity of the alpha(2)-macroglobulin promoter in HepG2 cells, whereas expression… CONTINUE READING