Akt mediates sequestration of the beta(2)-adrenergic receptor in response to insulin.

@article{Doronin2002AktMS,
  title={Akt mediates sequestration of the beta(2)-adrenergic receptor in response to insulin.},
  author={Sergey V. Doronin and Elena Shumay and Hsien-yu Wang and Craig C. Malbon},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 17},
  pages={
          15124-31
        }
}
The counterregulation of catecholamine action by insulin includes insulin-stimulated sequestration of the beta(2)-adrenergic receptor. Herein we examined the signaling downstream of insulin receptor activation, focusing upon the role of 1-phosphatidylinositol 3-kinase and the serine-threonine protein kinase Akt (also known as protein kinase B) in the internalization of beta(2)-adrenergic receptors. Inhibition of 1-phosphatidylinositol 3-kinase by LY294002 blocks insulin-induced sequestration of… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Similar Papers

Loading similar papers…