Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.

  title={Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.},
  author={Valentina E Evdokimova and Peter Ruzanov and Michael S Anglesio and Alexey V. Sorokin and Lev P. Ovchinnikov and Jonathan Buckley and Timothy Triche and Nahum Sonenberg and Poul H. B. Sorensen},
  journal={Molecular and cellular biology},
  volume={26 1},
YB-1 is a broad-specificity RNA-binding protein that is involved in regulation of mRNA transcription, splicing, translation, and stability. In both germinal and somatic cells, YB-1 and related proteins are major components of translationally inactive messenger ribonucleoprotein particles (mRNPs) and are mainly responsible for storage of mRNAs in a silent state. However, mechanisms regulating the repressor activity of YB-1 are not well understood. Here we demonstrate that association of YB-1… CONTINUE READING