Akt like a woman: gender differences in susceptibility to cardiovascular disease.

@article{Sugden2001AktLA,
  title={Akt like a woman: gender differences in susceptibility to cardiovascular disease.},
  author={Peter H. Sugden and Angela Clerk},
  journal={Circulation research},
  year={2001},
  volume={88 10},
  pages={975-7}
}
The cellular homolog of v-akt was cloned in the early 1990s and was termed c-Akt (or simply Akt). Largely on the basis of its sequence similarity to both protein kinases A and C, it was concluded that Akt (alternatively known as protein kinase B [PKB]) represented a Ser-/Thrprotein kinase. Three mammalian genes have been identified, with transcripts of akt1andakt2 being highly expressed in heart. The explosion of interest in Akt was the direct consequence of the realization that it is an… CONTINUE READING