Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients.

@article{Tokunaga2006AktIF,
  title={Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients.},
  author={Eriko Tokunaga and Yasue Kimura and Eiji Oki and Naoyuki Ueda and Motonori Futatsugi and Kojiro Mashino and Manabu Yamamoto and Masahiko Ikebe and Yoshihiro Kakeji and Hideo Baba and Yoshihiko Maehara},
  journal={International journal of cancer},
  year={2006},
  volume={118 2},
  pages={284-9}
}
Akt/PKB is a serine/threonine kinase that plays an important role in survival when cells are exposed to different apoptotic stimuli. Aberrant activation of Akt/PKB in breast carcinoma is associated with poor prognosis and resistance to endocrine therapy and chemotherapy. The Akt signaling pathway currently attracts considerable attention as a new target for effective therapeutic strategies. We therefore investigated the relationship between activation of Akt and clinicopathologic variables… CONTINUE READING