Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

@article{Niulescu2016AktII,
  title={Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)},
  author={George Mihai Nițulescu and Denisa Margină and Petras Juzenas and Qian Peng and Octavian Tudorel Olaru and Emmanouil Saloustros and Concettina Fenga and Demetrios A. Spandidos and Massimo Libra and Aristidis M. Tsatsakis},
  journal={International Journal of Oncology},
  year={2016},
  volume={48},
  pages={869 - 885}
}
Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are currently the focus of anticancer drug development. Protein kinase B, also known as Akt, plays a central role in many types of cancer and has been validated as a therapeutic target nearly two decades ago. This review summarizes the intracellular functions of Akt as a pivotal point of converging signaling pathways involved in cell growth… 
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