Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism.

  title={Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism.},
  author={Ewan F Dunn and Rachel Fearns and John H. Connor},
  journal={Journal of virology},
  volume={83 22},
Many viruses activate the phosphatidylinositol 3'-kinase (PI3k)/Akt intracellular signaling pathway to promote viral replication. We have analyzed whether a rapidly replicating rhabdovirus, vesicular stomatitis virus (VSV), requires the PI3k/Akt signaling pathway for its replication. Through the use of chemical inhibitors of PI3k and Akt, we show that VSV replication and cytopathic effects do not require activation of these kinases. Inhibitors that block the activating phosphorylations of Akt… CONTINUE READING


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