Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade.


SHIP is an SH2-containing inositol-5-phosphatase expressed in hematopoietic cells. It hydrolyzes the PI3K product PI(3,4,5)P(3) and blunts the PI3K-initiated signaling pathway. Although the PI3K/Akt pathway has been shown to be important for osteoclastogenesis, the molecular events involved in osteoclast differentiation have not been revealed. We… (More)
DOI: 10.4049/jimmunol.1101254


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