Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17.

@article{Catalucci2009AktIS,
  title={Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17.},
  author={Daniele Catalucci and Michael V. G. Latronico and Marcello Ceci and Francesca M. E. Rusconi and Howard S. Young and Paolo Gallo and Marco Santonastasi and Alfonso Bellacosa and Joan Brown and Gianluigi Condorelli},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 41},
  pages={28180-7}
}
Cardiomyocytes adapt to physical stress by increasing their size while maintaining cell function. The serine/threonine kinase Akt plays a critical role in this process of adaptation. We previously reported that transgenic overexpression of an active form of Akt (Akt-E40K) in mice results in increased cardiac contractility and cell size, as well as improved sarcoplasmic reticulum (SR) Ca(2+) handling. Because it is not fully elucidated, we decided to study the molecular mechanism by which Akt… CONTINUE READING