Akt in the pathogenesis of COPD

  title={Akt in the pathogenesis of COPD},
  author={Steven Bozinovski and Ross Vlahos and Michelle J. Hansen and Ken Liu and Gary P. Anderson},
  booktitle={International journal of chronic obstructive pulmonary disease},
In this review we consider the therapeutic potential of targeting Akt for the treatment of COPD. Akt is a serine/threonine protein kinase that functions as a signaling intermediate linked to multiple signaling programs involved in survival, inflammation, and growth. Akt is closely associated with key membrane-bound receptors and represents a convergent integration point for multiple stimuli implicated in COPD pathogenesis. Persistent activation of Akt secondary to somatic mutations in… CONTINUE READING


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