Akt in prostate cancer: possible role in androgen-independence.

  title={Akt in prostate cancer: possible role in androgen-independence.},
  author={Paramita M. Ghosh and Shazli N Malik and Roble B. Bedolla and Jeffrey I. Kreisberg},
  journal={Current drug metabolism},
  volume={4 6},
Akt, a downstream effector of phosphatidylinositol 3-kinase (PI3K), has often been implicated in prostate cancer. Studies in prostate tumor cell lines revealed that Akt activation is probably important for the progression of prostate cancer to an androgen-independent state. Investigations of human prostate cancer tissues show that although there is neither Akt gene amplification nor enhanced protein expression in prostate cancer compared to normal tissue, poorly differentiated tumors exhibit… CONTINUE READING