Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

  title={Akt enhances Mdm2-mediated ubiquitination and degradation of p53.},
  author={Yoko Ogawara and Shohei Kishishita and Toshiyuki Obata and Yuko Isazawa and Toshiaki Suzuki and Keiji Tanaka and Norihisa Masuyama and Yukiko Gotoh},
  journal={The Journal of biological chemistry},
  volume={277 24},
p53 plays a key role in DNA damage-induced apoptosis. Recent studies have reported that the phosphatidylinositol 3-OH-kinase-Akt pathway inhibits p53-mediated transcription and apoptosis, although the underlying mechanisms have yet to be determined. Mdm2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 and serves as a good substrate for Akt. In this study, we find that expression of Akt reduces the protein levels of p53, at least in part by enhancing the… CONTINUE READING
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