Akt-dependent transformation: there is more to growth than just surviving

@article{Plas2005AktdependentTT,
  title={Akt-dependent transformation: there is more to growth than just surviving},
  author={David R. Plas and Craig B Thompson},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={7435-7442}
}
Activation of the Akt/PKB protein kinase family triggers increases in cell size, metabolism and survival. Akt coordinately regulates these fundamental cellular processes through phosphorylation-dependent inactivation of tumor suppressors and activation of trophic signaling. Akt signaling stimulates transport and metabolism of both glucose and amino acids, which in turn support mTOR-dependent increases in protein translation. In addition, Akt activation directs cells to undertake a metabolic… CONTINUE READING