Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.

  title={Akt-dependent regulation of NF-\{kappa\}B is controlled by mTOR and Raptor in association with IKK.},
  author={Han C. Dan and Matthew J. Cooper and Patricia C. Cogswell and Joseph A Duncan and Jenny P-Y Ting and Albert S Baldwin},
  journal={Genes & development},
  volume={22 11},
While NF-kappaB is considered to play key roles in the development and progression of many cancers, the mechanisms whereby this transcription factor is activated in cancer are poorly understood. A key oncoprotein in a variety of cancers is the serine-threonine kinase Akt, which can be activated by mutations in PI3K, by loss of expression/activity of PTEN, or through signaling induced by growth factors and their receptors. A key effector of Akt-induced signaling is the regulatory protein mTOR… CONTINUE READING


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