Akt-dependent potentiation of L channels by insulin-like growth factor-1 is required for neuronal survival.

@article{Blair1999AktdependentPO,
  title={Akt-dependent potentiation of L channels by insulin-like growth factor-1 is required for neuronal survival.},
  author={Leslie A. C. Blair and Kendra K Bence-Hanulec and Samar Mehta and Thomas Franke and David Kaplan and John Marshall},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 6},
  pages={1940-51}
}
The insulin-like growth factor-1 (IGF-1)/receptor tyrosine kinase recently has been shown to mediate neuronal survival and potentiate the activity of specific calcium channel subtypes; survival requires Akt, a serine/threonine kinase. We demonstrate here that Akt mediates the IGF-1-induced potentiation of L channel currents, but not that of N channels. Transient expression of wild-type, dominant-negative, and constitutively active forms of Akt in cerebellar granule neurons causes, respectively… CONTINUE READING
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