Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.

  title={Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.},
  author={Joyce V. Lee and Alessandro Carrer and Supriya A Shah and Nathaniel W. Snyder and Shuanzeng Wei and Sriram Venneti and Andrew J. Worth and Zuo-Fei Yuan and Hee-Woong Lim and Shichong Liu and Ellen E. Jackson and Nicole M. Aiello and Naomi Balzer Haas and Timothy R. Rebbeck and Alexander R. Judkins and Kyoung-Jae Won and Lewis A. Chodosh and Benjamin A Garcia and Ben Z. Stanger and Michael D. Feldman and Ian A Blair and Kathryn E Wellen},
  journal={Cell metabolism},
  volume={20 2},
Histone acetylation plays important roles in gene regulation, DNA replication, and the response to DNA damage, and it is frequently deregulated in tumors. We postulated that tumor cell histone acetylation levels are determined in part by changes in acetyl coenzyme A (acetyl-CoA) availability mediated by oncogenic metabolic reprogramming. Here, we demonstrate that acetyl-CoA is dynamically regulated by glucose availability in cancer cells and that the ratio of acetyl-CoA:coenzyme A within the… CONTINUE READING
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