Akt and its downstream targets play key roles in mediating dormancy in land snails.

@article{Ramnanan2007AktAI,
  title={Akt and its downstream targets play key roles in mediating dormancy in land snails.},
  author={Christopher J Ramnanan and Amy G. Groom and Kenneth B. Storey},
  journal={Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology},
  year={2007},
  volume={148 3},
  pages={245-55}
}
Estivation, a state of aerobic dormancy, facilitates survival during adverse environmental conditions and is characterized at the molecular level by regulatory protein phosphorylation. The Akt (protein kinase B) signaling pathway regulates diverse responses in cells and the present study analyzes its role in the estivating desert snail Otala lactea. Kinetic analysis (maximal velocity, substrate affinities) determined that Akt was activated in tissues of estivating snails and Western blotting… CONTINUE READING

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