Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology.

@article{Plas2001AktAB,
  title={Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology.},
  author={David R. Plas and Sunit Talapatra and Aimee L Edinger and Jeffrey C. Rathmell and Craig B Thompson},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 15},
  pages={12041-8}
}
A comparison of Akt- and Bcl-x(L)-dependent cell survival was undertaken using interleukin-3-dependent FL5.12 cells. Expression of constitutively active Akt allows cells to survive for prolonged periods following growth factor withdrawal. This survival correlates with the expression level of activated Akt and is comparable in magnitude to the protection provided by the anti-apoptotic gene Bcl-x(L). Although both genes prevent cell death, Akt-protected cells can be distinguished from Bcl-x(L… CONTINUE READING