Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors

@article{Murayama2007AktAI,
  title={Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors},
  author={Kazushige Murayama and Taichi Kimura and Masahito Tarutani and Maya Tomooka and Ryohei Hayashi and Masaru Okabe and Kazuhiko Nishida and Satoshi Itami and Ichiro Katayama and Toru Nakano},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={4882-4888}
}
Various common signaling pathways maintain tissue stem cells, including Notch and Wnt/β-catenin signals. Phosphoinositide-3 kinase (PI3K)/Akt signaling regulates the ‘stemness’ of several stem cells in culture, specifically in maintaining embryonic stem and neural stem cells, and in deriving embryonic germ cells from primordial germ cells. We examined the effect of Akt signaling in epidermal cells in transgenic mice expressing an Akt-Mer fusion protein whose kinase activity was conditionally… CONTINUE READING