Akt activation by human T-cell leukemia virus tax oncoprotein

  title={Akt activation by human T-cell leukemia virus tax oncoprotein},
  author={Mathew A. Cherian and H. Baydoun and Jacob Al-Saleem and M. Kvaratskhelia and P. Green and L. Ratner},
  pages={P54 - P54}
Human T-Cell Leukemia Virus type 1 (HTLV-1), the etiological agent of Adult T-Cell Leukemia, expresses the viral oncoprotein Tax1. In contrast, HTLV-2, which expresses Tax2, is non-leukemogenic. One difference between these homologous proteins is the presence of a C-terminal PDZ (post synaptic density protein) domain binding motif (PBM), previously reported to be important for non-canonical nuclear factor kappa B (NFkappaB) activation. In contrast, the current study finds no defect in non… Expand
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