Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

@article{Brunet1999AktPC,
  title={Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor},
  author={Anne Sophie Brunet and Azad Bonni and Michael J. Zigmond and Michael Z. Lin and Peter Juo and Linda S. Hu and Michael J. Anderson and Karen C. Arden and John Blenis and Michael E. Greenberg},
  journal={Cell},
  year={1999},
  volume={96},
  pages={857-868}
}
Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9. In this study, we demonstrate that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors. In the presence of survival factors, Akt phosphorylates FKHRL1, leading to FKHRL1's association with 14-3-3 proteins and FKHRL1… CONTINUE READING
Highly Influential
This paper has highly influenced 226 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
2,303 Citations
53 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 2,303 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Withdrawal of survival factors results in activa1318 – 1321 . tion of the JNK pathway in neuronal cells leading to Fas ligand

  • M. Karin
  • 1999

Similar Papers

Loading similar papers…