Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

@article{Wang2012AktMediatedRO,
  title={Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation},
  author={Richard C. Wang and Yongjie Wei and Zhenyi An and Zhongju Zou and Guanghua Xiao and G. Bhagat and M. White and Julia Reichelt and Beth Levine},
  journal={Science},
  year={2012},
  volume={338},
  pages={956 - 959}
}
Getting Autophagy to Akt The protein kinase Akt is often activated in human cancers and is thought to promote tumor formation. One way in which it may do so is to inhibit autophagy (a process by which the cell digests its own proteins or organelles, especially damaged ones). Wang et al. (p. 956, published online 25 October; see the Perspective by Koren and Kimchi) provide a direct molecular mechanism by which Akt regulates autophagy. Beclin, a component of the autophagy machinery, appears to be… Expand

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