Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.

Abstract

BACKGROUND Children with neurofibromatosis type 1 (NF1) develop optic pathway gliomas, which result from impaired NF1 protein regulation of Ras activity. One obstacle to the implementation of biologically targeted therapies is an incomplete understanding of the individual contributions of the downstream Ras effectors (mitogen-activated protein kinase kinase… (More)
DOI: 10.1093/neuonc/nou329

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Cite this paper

@article{Kaul2015AktOM, title={Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.}, author={Aparna Kaul and Joseph A. Toonen and Patrick J Cimino and Scott M. Gianino and David H. Gutmann}, journal={Neuro-oncology}, year={2015}, volume={17 6}, pages={843-53} }