Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

  title={Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo},
  author={S. Bodine and T. Stitt and M. Gonzalez and W. O. Kline and Gretchen L. Stover and R. Bauerlein and E. Zlotchenko and A. Scrimgeour and J. Lawrence and D. Glass and G. Yancopoulos},
  journal={Nature Cell Biology},
  • S. Bodine, T. Stitt, +8 authors G. Yancopoulos
  • Published 2001
  • Biology, Medicine
  • Nature Cell Biology
  • Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. [...] Key Method The roles of two signalling pathways implicated in muscle hypertrophy on the basis of findings in vitro, Akt/mTOR (mammalian target of rapamycin) and calcineurin/NFAT (nuclear factor of activated T cells), were investigated in several models of skeletal muscle hypertrophy and atrophy in vivo. The Akt/mTOR pathway was upregulated during hypertrophy and downregulated during muscle atrophy…Expand Abstract
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