Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria.

@article{Kennedy1999AktProteinKB,
  title={Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria.},
  author={S G Kennedy and Eugene S. Kandel and Tanya Cross and Nissim Hay},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 8},
  pages={
          5800-10
        }
}
Growth factors signaling through the phosphoinositide 3-kinase/Akt pathway promote cell survival. The mechanism by which the serine/threonine kinase Akt prevents cell death remains unclear. We have previously shown that Akt inhibits the activity of DEVD-targeted caspases without changing the steady-state levels of Bcl-2 and Bcl-x(L). Here we show that Akt inhibits apoptosis and the processing of procaspases to their active forms by delaying mitochondrial changes in a caspase-independent manner… CONTINUE READING

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