Akt/PKB: one kinase, many modifications.

  title={Akt/PKB: one kinase, many modifications.},
  author={Guillermo J. Risso and Mat{\'i}as Blaustein and Berta Pozzi and Pablo Mammi and Anabella Srebrow},
  journal={The Biochemical journal},
  volume={468 2},
Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the regulation of a plethora of cellular processes triggered by a wide diversity of extracellular signals and is thus considered a key signalling molecule in higher eukaryotes. Deregulation of Akt signalling is associated with a variety of human diseases, revealing Akt-dependent pathways as an attractive target for therapeutic intervention. Since its discovery in the early 1990s, a large body of work has… CONTINUE READING
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